Professor Antonio Zaza
Vital: Born: Milano, January 13, 1956
Citizenship: Italian Education: 1981:
Graduation cum laude in Medicine (Università degli Studi di Milano)
1983: Board in Cardiology (Università degli Studi di Milano)
1982/86: Research Fellow (Centro di Fisiologia Clinica e Ipertensione, Università degli Studi di Milano)
1986/89: Post-doctoral Research Scientist (Dept. of Pharmacology, Columbia University, New York). Foreign languages: English, Spanish
Academic: 1990-2000: Assistant Professor of Physiology (Università degli Studi di Milano and MilanoBicocca)
2000- : Professor of Physiology (Università degli Studi Milano-Bicocca)
2004-2006: Vice-Chairman of the Dept. of Biotechnology and Bioscience (Università degli Studi Milano-Bicocca)
2004- : Faculty member of the PhD School in Translational Medicine (DIMET)
2006-2009: Chairman of the Graduation Course in Biology (Università degli Studi MilanoBicocca).
2016- : “Hein J. Wellens” Visiting Professor at CARIM, Maastricht University (NL) International member of PhD thesis-committees by foreign universities (Amsterdam, Edimburgh, Maastricht, Madrid, Utrecht, etc.). Participation to international organizations:
2002- : EWGCCE Nucleus member 2002-2004: Vice-chair of the Working Group on Cardiac Cellular Electrophysiology of the Europen Society of Cardiology
2004-2006: Chair of the Working Group on Cardiac Cellular Electrophysiology of the European Society of Cardiology 2005-2009: Member of the educational committee of the European Heart Rhythm Association (EHRA).
2007-2009: Member of the European Relation Committee for Research of the European Society of Cardiology
2017- : Member of the ESC Guideline Task Force for Supraventricular Arrhythmias Editorial Activity 2012 – : Deputy Editor of Europace (Official Journal of the European Heart Rhythm Association)
2018 – : Associate Editor of Frontiers Arrhythmias Member of the Editorial Board of: Journal of Cardiovascular Pharmacolgy, Reviewer for international journals in the field of cardiovascular cell physiology and pharmacology (Cardiovasc. Res., Circulation, Circ.Res., J. Physiol, J Pharmacol. Exp Ther, J.Mol.Cell.Cardiol. etc.). Referee for the Ministry of University and Research (MIUR) and foreign (Israel, Spain, Holland) funding agencies.
Articles: 110 (Scopus indexed) Reviews and book chapters: 32 Books (as Editor): 2 Funding: The laboratory directed by Dr. Zaza works on both public and private (industry): 2004- European FP6 Strategic Project “SC&CR”: “Application and process optimization of human cells for cardiac repair” 2005-: MIUR Interlink Collaborative Project with INSERM U-637, Montpellier FR 2007-: Contract with the Ministry of University and Research (MIUR) for an investigation on the myocardial effects of chronic hypoxia 2009- Grants from Gilead (Palo Alto, USA) for investigation on the Late Na current 2014- Grants for CVie (Taiwan) for investigation on pharmacological modulation of SERCA activity Field of expertise: Cardiac cell pathophysiology and pharmacology, with a focus on: mechanisms of cardiac pacemaking, mechanisms of cardiac repolarization, intracellular calcium dynamics and excitation-contraction coupling. Selected publications: Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A. Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1- F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res. 2017 Apr 1;113(5):531-541. Ronchi C, Torre E, Rizzetto R, Bernardi J, Rocchetti M, Zaza A. Late sodium current and intracellular ionic homeostasis in acute ischemia. Basic Res Cardiol. 2017 Mar;112(2):12. Dias da Silva VJ, Tobaldini E, Rocchetti M, Wu MA, Malfatto G, Montano N, Zaza Modulation of sympathetic activity and heart rate variability by ivabradine. Cardiovasc Res. 2015 Oct 1;108(1):31-8. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O’Rourke B, Weiss JN, Varró A, Zaza. Deranged sodium to sudden death. J Physiol. 2015 Mar 15;593(6):1331-45 Moreno C, de la Cruz A, Oliveras A, Kharche SR, Guizy M, Comes N, Starý T, Ronchi C, Rocchetti M, Baró I, Loussouarn G, Zaza A, Severi S, Felipe A, Valenzuela C. Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains. Cardiovasc Res. 2015 Feb 1;105(2):223-32. Bartolucci C, Altomare C, Bennati M, Furini S, Zaza A, Severi S. Combined action potential- and dynamic-clamp for accurate computational modelling of the cardiac IKr current. J Mol Cell Cardiol. 2015 Feb;79:187-94. Zaza A, Rocchetti M. Calcium store stability as an antiarrhythmic endpoint. Curr Pharm Des. 2015;21(8):1053-61. Review. Rizzetto R, Rocchetti M, Sala L, Ronchi C, Villa A, Ferrandi M, Molinari I, Bertuzzi F, Zaza A. Late sodium current (INaL) in pancreatic β-cells. Pflugers Arch. 2015 Aug;467(8):1757-68. Zaza A. Control of the cardiac action potential: The role of repolarization dynamics. J Mol Cell Cardiol. 2009; 48(1):106-11 Banyasz T, Horvath B, Virag L et al. Reverse rate dependency is an intrinsic property of canine cardiac preparations. Cardiovasc Res. 2009; 1;84(2):237-44. Zanoni I, Ostuni R, Capuano G et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature. 2009; 460:264-268. Severi S, Corsi C, Rocchetti M et al.Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J. 2009; 96:3862-3872. Zaza A, Belardinelli L, Shryock JC. Pathophysiology and pharmacology of the cardiac “late sodium current.” Pharmacol Ther. 2008;119:326-339. Rocchetti M, Alemanni M, Mostacciuolo G et al. Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure model. J Pharmacol Exp Ther. 2008;326:957-965. Malfatto G, Zaza A, Facchini M. Different effects of antiarrhythmic drugs on the ratedependency of QT interval: a study with amiodarone and flecainide. J Cardiovasc Pharmacol. 2007;50:535-540. Rocchetti M, Freli V, Perego V et al.Rate dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle. J Physiol. 2006;574:183-193. Rocchetti M, Besana A, Mostacciuolo G et al. Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2- aminoethoxy)imino)androstane-6,17-dione hydrochloride]. J Pharmacol Exp Ther 2005;313:207- 215. Rocchetti M, Besana A, Mostacciuolo G, Ferrari P, Micheletti R, Zaza A. Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms. J Pharmacol Exp Ther2003;305:765-771. Rocchetti M, Besana A, Gurrola GB, Possani LD, Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol. 2001;534:721-732. Zaza A, Lombardi F. Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node. Cardiovasc Res. 2001;50:434-442. Rocchetti M, Malfatto G, Lombardi F, Zaza A. Role of the input/output relation of sinoatrial myocytes in cholinergic modulation of heart rate variability. J Cardiovasc Electrophysiol. 2000;11:522-530. Zaza A, Rocchetti M, Brioschi A, Cantadori A, Ferroni A. Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential. Circ Res. 1998;82:947-956. Zaza A, Micheletti M, Brioschi A, Rocchetti M. Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes. J Physiol. 1997;505:677-688. Zaza A, Rocchetti M, DiFrancesco D. Modulation of the hyperpolarization-activated current (I(f)) by adenosine in rabbit sinoatrial myocytes. Circulation. 1996;94:734-741. Zaza A, Robinson RB, DiFrancesco D. Basal responses of the L-type Ca2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node. J Physiol. 1996;491:347-355
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